Invert-Prospective Phase II Randomized Trial of Involved Nodal Versus Elective Neck RadioTherapy

This study compares two radiation therapy approaches for head and neck cancers: standard elective neck radiation (treating a wider area including lymph nodes that appear cancer-free) versus involved nodal radiation (treating only lymph nodes that show signs of cancer). The goal is to see if a more targeted approach has fewer side effects with the same cancer control. **You may be eligible if...** - You have confirmed squamous cell carcinoma of the throat, voicebox (larynx), or upper throat (oropharynx or hypopharynx) - You have measurable disease that can be seen on imaging - You are in adequate overall health for radiation treatment **You may NOT be eligible if...** - Your cancer is from an unknown primary site - You have distant metastases (spread beyond the neck/head region) - You have had previous head and neck radiation Talk to your doctor to see if this trial is right for you.