RecruitingNot ApplicableNCT06478784

Effects of Resistance Training in Multiple Sclerosis: a Randomized Trial.

Effects of Resistance Training in Multiple Sclerosis: a Randomized Trial. ACTIVE (Physical Activity and Its Impact on Patients With Multiple Sclerosis.)

Sponsor

Hospital Clínico Universitario de Valladolid

Enrollment

50 participants

Start Date

Jan 1, 2024

Study Type

INTERVENTIONAL

Conditions

Multiple Sclerosis

Summary

This is a longitudinal study to examine the effects of a short-term training program on neurofilamet and GFAP plasma levels. Participants will be divided in two groups: control group (moderate aerobic training) and active group (resistance training). The change in biomarkers will be analyzed pre and post intervention in both groups. Differences between groups will be also evaluated by investigators.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study tests whether a structured resistance training (strength exercise) program can reduce disability and improve physical function in people with multiple sclerosis (MS), a disease that can affect movement, balance, and strength. **You may be eligible if...** - You are 18 or older with a confirmed MS diagnosis - Your disability level is mild to moderate (EDSS score 4 or below — meaning you can walk without aid) - Your condition is clinically stable and on a stable medication regimen **You may NOT be eligible if...** - You have severe disability or cannot walk without assistance - You are currently experiencing a relapse (disease flare-up) - You have conditions that make exercise unsafe (such as severe heart or bone problems) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERResistance training

The experimental group (ACTIVE GROUP) will perform a circuit-based muscular strength program at high intensity three days per week for 10 weeks. Each session will last approximately 45 minutes. The Resistance training program will be supervised by staff from the Department of Health Sciences and Sports of the Miguel de Cervantes European University of Valladolid and will be carried out at the facilities of the Miguel de Cervantes European University of Valladolid.

OTHERLow aerobic training

Patients assigned to this group will perform exercise in static bicycle during 45 minutes three days a week, with a duration of 10 weeks. This second group, despite performing the aerobic exercise, is considered control, since they will perform low-intensity aerobic exercise (50% of the maximum power developed in cycloergometer) The Resistance training program will be supervised by staff from the Department of Health Sciences and Sports of the Miguel de Cervantes European University of Valladolid and will be carried out at the facilities of the Miguel de Cervantes European University of Valladolid.