Effects of Resistance Training in Multiple Sclerosis: a Randomized Trial.
Effects of Resistance Training in Multiple Sclerosis: a Randomized Trial. ACTIVE (Physical Activity and Its Impact on Patients With Multiple Sclerosis.)
Hospital Clínico Universitario de Valladolid
50 participants
Jan 1, 2024
INTERVENTIONAL
Conditions
Summary
This is a longitudinal study to examine the effects of a short-term training program on neurofilamet and GFAP plasma levels. Participants will be divided in two groups: control group (moderate aerobic training) and active group (resistance training). The change in biomarkers will be analyzed pre and post intervention in both groups. Differences between groups will be also evaluated by investigators.
Eligibility
Inclusion Criteria7
- \- Diagnosis of multiple sclerosis according to the 2017 Mc Donald criteria (Thompson A et al).
- \- Age > 18 years - up to no age limit
- \- Disability assessed by the EDSS (Expanded disability status scale) with a score less than or equal to 4.
- \- Clinical stability. Not having had an outbreak of the disease in the last 6 months.
- \- No changes in the disease-modifying treatment in the last 6 months or no treatment.
- \- Radiological stability. Patients with last MRI (magnetic resonance imaging) performed without inflammatory activity (absence of new lesions on T2 sequences or lesions that enhance with gadolinium).
- \- They must sign the informed consent
Exclusion Criteria3
- \- Patients with a high level of physical activity according to the International Physical Activity Questionnaire(IPAQ) or latest WHO (World Health Organization) recommendations on physical activity
- \- Pregnant or breastfeeding patients.
- \- Concomitant pathologies that limit the performance of physical exercise
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Interventions
The experimental group (ACTIVE GROUP) will perform a circuit-based muscular strength program at high intensity three days per week for 10 weeks. Each session will last approximately 45 minutes. The Resistance training program will be supervised by staff from the Department of Health Sciences and Sports of the Miguel de Cervantes European University of Valladolid and will be carried out at the facilities of the Miguel de Cervantes European University of Valladolid.
Patients assigned to this group will perform exercise in static bicycle during 45 minutes three days a week, with a duration of 10 weeks. This second group, despite performing the aerobic exercise, is considered control, since they will perform low-intensity aerobic exercise (50% of the maximum power developed in cycloergometer) The Resistance training program will be supervised by staff from the Department of Health Sciences and Sports of the Miguel de Cervantes European University of Valladolid and will be carried out at the facilities of the Miguel de Cervantes European University of Valladolid.
Locations(1)
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NCT06478784