RecruitingNot ApplicableNCT06480864

Adebrelimab Plus Apatinib for Maintenance Therapy of Extensive Stage Small Cell Lung Cancer

Adebrelimab Plus Apatinib for Maintenance Treatment of Extensive Stage Small Cell Lung Cancer After First-line Induction with Adebrelimab Plus Chemotherapy (CLOG2402-ADAPT): a Multi-center, Single-arm, Phase 2 Clinical Trial


Sponsor

Yunpeng Liu

Enrollment

38 participants

Start Date

Aug 9, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

To evaluate the efficacy and safety of maintenance therapy with Adebrelimab plus Apatinib for extensive stage small cell lung cancer after first-line induction of Adebrelimab plus chemotherapy.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether two medications — adebrelimab (an immunotherapy drug) and apatinib (a drug that blocks blood vessel growth in tumors) — can work together to maintain remission in people with extensive-stage small cell lung cancer (a fast-growing type of lung cancer that has spread beyond the lungs) after initial chemotherapy. **You may be eligible if...** - You are 18 or older - You have been diagnosed with extensive-stage small cell lung cancer (confirmed by biopsy) - You have not yet received any treatment for this stage of the disease - Your general health is good enough to perform daily activities (ECOG score 0–2) - Any brain tumors are stable and not causing symptoms **You may NOT be eligible if...** - You have already received chemotherapy, immunotherapy, or other systemic treatment for this cancer - You have active autoimmune disease or are on immunosuppressive therapy - You have severe heart, liver, or kidney problems - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGAdebrelimab Injection

Adebrelimab injection (1200mg) will be administered by intravenous infusion during the induction phase and maintenance phase on day 1 in a 3-week treatment cycle.

DRUGApatinib Mesylate Tablets

Apatinib mesylate tablets (250 mg) will be administered orally in a 3-week treatment cycle, once a day.

DRUGCarboplatin

Carboplatin (AUC 4-5mg/mL/min) intravenous infusion will be administered during the induction phase on day 1 in a 3-week treatment cycle.

DRUGCisplatin

Cisplatin (75mg/m2) intravenous infusion will be administered during the induction phase on day 1 in a 3-week treatment cycle.

DRUGEtoposide

Etoposide(100mg/m2) intravenous infusion will be administered during the induction phase from day 1 to 3 in a 3-week treatment cycle.


Locations(2)

The First Hospital of China Medical University

Shenyang, Liaoning, China

The First Hospital of China Medical University

Shenyang, China

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NCT06480864


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