RecruitingEarly Phase 1NCT06485661
Effect of Captopril on GLS in Duchenne Myodystrophy
Intermediate Term Effect of Captopril on Left Ventricle Global Longitudinal Strain in Patients With Duchenne Myodystrophy
Sponsor
Ain Shams University
Enrollment
20 participants
Start Date
Jan 1, 2024
Study Type
INTERVENTIONAL
Conditions
Summary
To outline the intermediate term effect of prescribing Captopril as an add on therapy on Left ventricular functions as measured by Global longitudinal strain in patients with Duchenne myodystrophy (DMD)
Eligibility
Sex: MALEMin Age: 6 Years
Inclusion Criteria1
- Genetically confirmed Duchenne myodystrophy (DMD) patients with abnormal GLS < -18% with minimum age of 6 years old.
Exclusion Criteria3
- Any patient who refuses to sign an informed consent.
- Contraindication to ACEI: hypersensitivity - renal impairment - bilateral renal artery stenosis - aortic valve stenosis - hyperkalemia - hypotension.
- Reduced ejection fraction below 50%.
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Interventions
DRUGCaptopril Tablets
Patients will be given captopril to see effect on global longitudinal strain
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06485661
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