RecruitingNot ApplicableNCT06492109

The Peripheral Blood Multi-Omics Study on Sleep Loss

The Peripheral Blood Multi-Omics Study on the Association of Sleep Loss With Aging and Alzheimer's Disease

Sponsor

First Affiliated Hospital of Zhejiang University

Enrollment

60 participants

Start Date

Jun 20, 2024

Study Type

INTERVENTIONAL

Conditions

Cognitive Decline Alzheimer Disease Aging Healthy Lifestyle Shift-work Disorder Sleep Deprivation

Summary

Sleep plays a role in cognitive processes such as memory processing, attention processing, and overall cognitive function. In recent years, the bidirectional relationship between sleep loss and aging, as well as related neurodegenerative diseases, has garnered widespread attention. Sleep disorders are a typical clinical manifestation of neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease and are closely related to the progression of these diseases. However, current research has yet to fully elucidate the physiological responses to sleep loss across different ages and cognitive levels, as well as the association and molecular basis between sleep loss, aging, and neurodegenerative diseases. This study aims to comprehensively characterize the transcriptional and metabolic changes in peripheral blood under sleep loss in populations of different ages and cognitive levels using multi-omics approaches and to preliminarily explore the role of sleep loss in aging and AD.

Eligibility

Min Age: 18 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This study is analyzing blood samples from people experiencing sleep deprivation (such as healthcare workers doing overnight shifts) to better understand the biological changes that happen in the body when we lose sleep. Researchers will study multiple biological systems (multi-omics) to identify sleep-loss biomarkers. **You may be eligible if...** - You meet the specific inclusion criteria for your arm of the study (e.g., healthcare shift workers) - You are willing to provide blood samples and follow study procedures - You are able to give informed consent **You may NOT be eligible if...** - You regularly take medications that affect sleep (like opioids, benzodiazepines, or sleeping pills) - You have a history of alcohol or substance abuse, significant neurological conditions (like epilepsy or stroke), or serious psychiatric disorders - You have difficulty understanding study procedures due to language barriers or cognitive issues Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALSleep manipulation

This study will collect the MMSE results as a supplement to the MoCA. The sleep status of subjects will be screened using the Morningness-Eveningness Questionnaire (MEQ), Pittsburgh Sleep Quality Index (PSQI), and Epworth Sleepiness Scale (ESS). Subjects must maintain regular sleep and diet before sample collection. Peripheral blood samples will be taken the day before, the day of, and the day after acute sleep deprivation, whether experimentally induced (controlled) or naturally occurring (passive), along with assessment scales including anxiety and depression assessments. For chronic sleep deprivation (≥7 days), blood samples will be collected before and after the deprivation period, with anxiety, depression, and cognitive assessments. Experimentally induced sleep deprivation takes place under controlled laboratory conditions, whereas passive sleep deprivation arises from external factors such as aging or shift work.