RecruitingNot ApplicableNCT06496646

Antidepressant Adherence for Depressed Adults in Primary Care

Antidepressant Medication Adherence in Adults With Depression

Sponsor

University of Pennsylvania

Enrollment

525 participants

Start Date

Mar 19, 2025

Study Type

INTERVENTIONAL

Conditions

Depression

Summary

The goal of this study is to test ways to help people improve their health and manage their medication for depression. This study will measure both medication adherence and depression outcomes.

Eligibility

Min Age: 21 YearsMax Age: 64 Years

Inclusion Criteria9

Penn Medicine primary care outpatients
Clinical diagnosis of major depressive disorder
A score of 10+ on the Patient Health Questionnaire 9 (PHQ-9)
Age 21 to 64 years at the time of study entry
Prescribed an antidepressant by their primary care clinician
Express interest in taking antidepressant medication
Own a cell phone
Capable of using the electronic pill bottle
English-speaking

Exclusion Criteria7

Treated with antidepressants in the past 90 days
Pregnant or breastfeeding
An active substance use disorder other than nicotine
A lifetime history of treatment for bipolar disorder or schizophrenia
Hospital admission or emergency department visit for suicidal symptoms in the past year
Lack capacity to provide informed consent
Using antidepressant more than 10 days at baseline assessment