Non-invasive Tools for PSVD Diagnosis
Noninvasive Tools for the Diagnosis of Porto-sinusoidal Vascular Disease: a Single-center, Prospective, Cohort Study
Nanfang Hospital, Southern Medical University
1,000 participants
Feb 28, 2024
OBSERVATIONAL
Conditions
Summary
Patients treated with platinum-based chemotherapy drugs have the probability of developing PSVD. The diagnosis of PSVD depends on liver biopsy. In addition, the level of portal vein pressure has guiding value in the diagnosis and prognosis of PSVD. Many studies have shown that liver and spleen stiffness have high accuracy in diagnosis and prognosis. The purpose of this study is to evaluate the efficacy of the combination of liver and spleen stiffness in the diagnosis of PSVD and to search for effective biomarkers for the diagnosis of PSVD through a single-center, prospective, observational study.
Eligibility
Inclusion Criteria3
- Received platinum chemotherapy for organ tumors;
- Ages 18-80;
- sign the informed consent voluntarily.
Exclusion Criteria7
- Liver pathology suggested cirrhosis;
- Underwent liver transplantation;
- Combined with hepatocellular carcinoma exceeding Milan criteria;
- Complicated with severe heart, kidney, or lung failure;
- Pregnant or lactating women;
- Data is seriously missing;
- Patients were judged not suitable for participation in this study by the researchers.
Interventions
liver and spleen stiffness measurement are non-invasive tools for evaluation of cirrhosis and portal hypertension
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT06500403