Predicting Acute-on-Chronic Liver Failure After Surgical Intervention in Chronic Liver Disease

This study aims to identify markers in the blood that can predict whether a patient with chronic liver disease will develop a serious complication called acute-on-chronic liver failure (ACLF) after surgery. ACLF is a rapid deterioration of liver function that can be life-threatening. **You may be eligible if...** - You are 18 years old or older - You have chronic liver disease with or without cirrhosis, or non-cirrhotic portal hypertension - You are scheduled for a surgical procedure - You are able to understand the study information and provide written consent **You may NOT be eligible if...** - You are pregnant or breastfeeding - You are having surgery only as palliative cancer care - You have severe diseases in other organ systems - You are HIV-positive - You have had a liver or organ transplant - You have acute or sudden liver failure without pre-existing liver disease Talk to your doctor to see if this trial is right for you.