RecruitingNCT04578301

Predicting Acute-on-Chronic Liver Failure After Surgical Intervention in Chronic Liver Disease

Sponsor

University Hospital, Bonn

Enrollment

200 participants

Start Date

Sep 22, 2020

Study Type

OBSERVATIONAL

Conditions

Surgery Liver Cirrhosis Acute-On-Chronic Liver Failure Portal Hypertension Non-Cirrhotic Portal Hypertension

Summary

Prospective, observational study to define precipitants and predictors of development of Acute-on-Chronic Liver Failure (ACLF) after surgical interventions, allowing to develop a risk stratification for elective procedures in cirrhotic patients. As well as identifying molecular mechanisms of post-interventional ACLF and thus preparing the ground for development of new therapeutic approaches.

Eligibility

Min Age: 18 Years

Inclusion Criteria8

Male or female adult (≥18 years) patient
With or without liver cirrhosis (diagnosed either histologically or by a combination of clinical, laboratory and radiological signs)
Or Non-cirrhotic portal hypertension
Non-pregnant, non-lactating females
Ability to understand the patient information and to personally sign and date the informed consent to participate in the study
The patient is co-operative and available for the entire study
Provided written informed consent
Indication for surgical intervention

Exclusion Criteria8

Pregnant or lactating females
Patients undergoing surgery as form of palliative cancer therapy
Presence or history of severe extra-hepatic diseases
HIV-positive patients
Previous liver or other transplantation
Patients with acute or subacute liver failure without underlying cirrhosis
Patients who decline to participate
Physician´s denial (e.g. the investigator considers that the patient will not follow the protocol scheduled)