Biomarkers in Parkinsonian Syndromes

This study is looking for blood and tissue markers (biomarkers) to help identify and distinguish different types of Parkinson's disease and related movement disorders (parkinsonian syndromes) earlier and more accurately. **You may be eligible if...** - You have symptoms of parkinsonism, regardless of how long you've had them (both early and established disease are included) - You are a healthy person with no neurological disease willing to serve as a comparison participant - You are willing to provide written informed consent **You may NOT be eligible if...** - Your parkinsonism is caused by a medication (such as antipsychotics, lithium, or metoclopramide) - Your parkinsonism is due to a metabolic condition (such as Wilson's disease) - You have structural brain lesions on MRI that explain your symptoms (such as hydrocephalus or a brain tumor) - You have another serious illness with a life expectancy of less than 5 years - You are currently participating in another interventional clinical study Talk to your doctor to see if this trial is right for you.