RecruitingNCT06501469

Biomarkers in Parkinsonian Syndromes

Prospective, Observational Study to Identify Biomarkers in Parkinsonian Syndromes

Sponsor

Non-profit organization for scientific research in Parkinson's disease and related disorders

Enrollment

200 participants

Start Date

Mar 23, 2022

Study Type

OBSERVATIONAL

Conditions

Multiple System Atrophy Parkinson Disease Progressive Supranuclear Palsy Atypical Parkinsonism Parkinsonism

Summary

This is a prospective observational study to identify biomarkers in parkinson syndromes. Patients with parkinsonian syndromes at the early stages of disease will be recruited and will be followed up until their established clinical diagnosis or for at least 5 years. In this population, imaging and wet biomarkers as well as clinical data will b systematically collected.

Eligibility

Inclusion Criteria5

IΙnclusion Criteria:
Written informed consent, including consent to monitoring
Patients with Parkinsonism and disease duration \< 2 years
Patients with Parkinsonism and disease duration \> 2 years
Healthy individuals without any neurological disease

Exclusion Criteria5

Drug-induced parkinsonism (eg, neuroleptics, lithium, valproic acid, metoclopramide).
Metabolic conditions related parkinsonism (eg, Wilson's disease, hypoparathyroidism).
Structural lesions on brain magnetic resonance imaging (MRI) that explain the symptoms, such as normal pressure hydrocephalus, moderate to severe chronic vascular encephalopathy, cerebral infarction, neoplasm
Other serious diseases that indicate a life expectancy of \<5 years.
Active participation in other interventional clinical studies