RecruitingNCT06508268

Language, Speech and Motor Function in MCI Due to AD and Alzheimer's Disease

Language, Speech and Motor Function in Mild Cognitive Impairment Due to AD and Alzheimer's Disease


Sponsor

Hanze University of Applied Sciences Groningen

Enrollment

208 participants

Start Date

Jul 12, 2024

Study Type

OBSERVATIONAL

Conditions

Summary

The goal of this observational cross-sectional study is to explore the characteristics of language, speech, and motor function in persons with Mild Cognitive Impairment due to Alzheimer's disease ("MCI due to AD") and persons with mild and moderate Alzheimer's disease ("AD"). This study aims to: * Explore motor, speech, and language functions in MCI due to AD and mild and moderate AD. * Combine the characteristics of motor, language, and speech functions to gain more insight into the association of language, speech, and motor changes during MCI due to AD and mild and moderate AD. Researchers will compare the outcomes to an age-matched control group without cognitive impairment. Participants will undergo: * Two motor function tests to assess gait and hand grip strength. * Four language and speech function tests to assess spontaneous speech and verbal fluency..


Eligibility

Plain Language Summary

Simplified for easier understanding

This study is examining how early Alzheimer's disease and mild cognitive impairment (MCI) affect a person's language, speech, and movement. Researchers want to better understand these changes to improve early detection and monitoring. **You may be eligible if...** - You have been diagnosed with mild cognitive impairment (MCI) likely due to Alzheimer's disease, based on established medical criteria - Or you have been diagnosed with Alzheimer's disease (amnestic or non-amnestic forms) - You are able to participate in language and motor function testing **You may NOT be eligible if...** - You do not meet the established diagnostic criteria for MCI due to Alzheimer's or Alzheimer's disease - You are unable to complete the required assessments Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALGAITRite walkway system OR 4-meter walking speed test

Gait will be assessed by the GAITRite walkway system OR the 4-meter walking speed test

BEHAVIORALJamar hand dynamometer

Hand grip strength will be assessed by a Jamar hand dynamometer

BEHAVIORALPicture description task

Characteristics Dutch/Frisian language Language and speech will be assessed by the Cookie Theft Picture-task (a picture description task from Berube et al., 2019)

BEHAVIORALAutobiographical semi-structured conversation

Characteristics Dutch/Frisian language and speech will be assessed by an autobiographical semi-structured conversation

BEHAVIORALVerbal fluency

The mental lexicon of Dutch/Frisian language will be assessed by a two verbal fluency tests, including letter fluency and categorical fluency


Locations(1)

Hanze University

Groningen, Netherlands

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NCT06508268


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