RecruitingNot ApplicableNCT06511310

Exercise, Brain Activity, and Weight Maintenance

Effects of Exercise Training on Brain Activity and Its Relation to Weight Maintenance and Appetite Regulation

Sponsor

Joslin Diabetes Center

Enrollment

15 participants

Start Date

Sep 15, 2025

Study Type

INTERVENTIONAL

Conditions

Obesity Weight Gain Bariatric Surgery Candidate Appetitive Behavior

Summary

This study aims to explore how HIIT influences brain function, neural and molecular pathways related to weight control, setting the stage for future obesity intervention research.

Eligibility

Min Age: 18 YearsMax Age: 70 Years

Inclusion Criteria5

Age 18-70 years
Body mass index (BMI) \>19 kg/m2 and body weight\< 250kg
Participants must have experienced a clinically significant weight regain, defined as over 10% of their maximum weight lost, within 1 to 5 years following their bariatric surgery. They will be asked to self-report their weight loss history. Participants must also provide the operative report from their bariatric surgery for reference.
In good general health with no conditions that could influence the outcome of the trial, and in the judgment of the investigator is a good candidate for the study based on review of available medical history, physical examination and clinical laboratory evaluations
Willing to adhere to the protocol requirements for the duration of the study

Exclusion Criteria21

Type 1 diabetes mellitus
Peripheral neuropathy with insensate feet
Recent blood donation within the last 2 months
Use of beta-blockers
Current pregnancy or breastfeeding
Active Heart or lung disease
Severe hypertension (systolic \>160 mmHg or diastolic \>90 mmHg)
Inability to exercise for any reason
Any known contraindication to exercise testing based on current ACSM guidelines
MRI contraindications, such as presence of pacemakers, aneurysm clips, artificial heart valves, ear implants, metal fragments, or foreign objects in the eyes, skin, or body
Known presence of a structural brain lesion (e.g. tumor, cortical infarct)
Presence of another neurologic disorder, which could impact findings (e.g. multiple sclerosis)
History of cardiovascular disease, stroke, congestive heart failure
Active hematological, renal, pulmonary or hepatic disorders
Active treatment for cancer
A history of active alcohol or substance abuse
Any significant systemic illness or unstable medical condition which could lead to difficulty complying with the study protocol
History of claustrophobia and inability to tolerate an MRI
Body weight \>250kgr and largest body diameter of 70cm as there is a certain weight and diameter limit of the MRI scanner
Unwilling or unable to return for study visits, undergo neuropsychological testing and MRI imaging
Left-handedness