Investigation to Understand and Optimize Psilocybin

This study is investigating psilocybin — the active compound in psychedelic mushrooms — as a potential treatment for major depressive disorder (MDD). The trial aims to better understand how psilocybin works and how to optimize its use in a clinical setting. **You may be eligible if...** - You have a current diagnosis of major depressive disorder (MDD) - Your depressive episode has been ongoing for at least 60 consecutive days - You have been medically evaluated and cleared to participate safely **You may NOT be eligible if...** - You have a personal or immediate family history of psychosis, schizophrenia, or bipolar disorder - You have active suicidal thoughts with a specific plan within the past 2 weeks - You have a history of seizures or significant cardiovascular disease - You have certain other psychiatric or medical conditions that could affect your safety or the study results - You are pregnant or planning to become pregnant Talk to your doctor to see if this trial is right for you.