RecruitingNot ApplicableNCT06513585

Primary Aldosteronism: Superselective Embolization vs. Laparoscopic Endocrine Curative Therapy

The First Affiliated Hospital of Xinjiang Medical University

Sponsor

Xinjiang Medical University

Enrollment

570 participants

Start Date

Aug 1, 2024

Study Type

INTERVENTIONAL

Conditions

Primary Aldosteronism Suprarenalectomy Super Selective Adrenal Artery Embolization

Summary

The aim of this study was to compare the efficacy and safety of adrenalectomy and superselective adrenal artery embolization in a prospective, multicenter, randomized controlled study. To provide a new interventional alternative therapy for primary aldosteronism.

Eligibility

Min Age: 18 YearsMax Age: 60 Years

Inclusion Criteria4

Age 18-60
Diagnosed with primary aldosteronism according to the 2016 Clinical guidelines of the International Endocrine Society
Primary aldosteronism diagnosed according to international guidelines Unilateral disease by AVS or PET-CT criteria
Patients and their family members signed informed consent and agreed to participate in the study

Exclusion Criteria10

A history of severe hypersensitivity to contrast media
Severe liver disease complications, such as thrombocytopenia, esophageal varices rupture bleeding, etc
Renal insufficiency (serum creatinine \> 176mmol/L or estimated glomerular filtration rate \< min.1.73m2)
Combined with other secondary hypertension, such as pheochromocytoma, hypercortisolism, renal vascular hypertension (such as renal artery stenosis), renin secretory tumor, renal parenchymatous hypertension, drug-induced hypertension (such as long-term use of glucocorticoids, contraceptives, estrogen, herbal medicines containing glycyrrhizin), pregnancy hypertension and other secondary hypertension
Combined with genetic diseases: such as false aldosteronism (Liddle syndrome), Bartter syndrome, familial hypokalemia and hypomagnesia (Gitelman syndrome)
Stroke, myocardial infarction and stent implantation occurred in the past 3 months
Serious other diseases, such as heart dysfunction (grade IV), acute infections, autoimmune diseases, various malignant tumors, etc
Participated in other clinical trials within the past 3 months
Pregnant, breastfeeding, or planning a pregnancy
Identify patients with alcohol allergy

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