RecruitingNCT06514170

Gastrointestinal Dysfunction in Aortic Surgery Patients

Assessment of Gastrointestinal Dysfunction Through GIDS Scale and Intestinal Damage Biomarkers in Critically Ill Patients Undergoing Aortic Surgery and Its Association With Clinical Outcomes.

Sponsor

Instituto Nacional de Cardiologia Ignacio Chavez

Enrollment

114 participants

Start Date

Jul 23, 2024

Study Type

OBSERVATIONAL

Conditions

Gastrointestinal dysfunction Surgical Complication Aortic Aneurysm Aortic Diseases Enteral Feeding Intolerance

Summary

The goal of this observational study is to determine the association of gastrointestinal dysfunction through the Gastrointestinal Dysfunction Scale (GIDS) tool and serum concentrations of citrulline and Intestinal fatty-acid binding protein (I-FABP) with primary \[calories received, protein received, parenteral nutrition requirement and 28-day mortality in the intensive care unit (ICU)\] and secondary (development of pneumonia, surgical and cardiovascular complications in the ICU, length of hospital and ICU stay, duration of mechanical ventilation) clinical outcomes in critically ill patients undergoing aortic surgery.

Eligibility

Min Age: 18 Years

Inclusion Criteria4

years of age or older.
Patients after surgical interventions (elective or urgency) on the aorta with cardiopulmonary bypass.
Invasive mechanical ventilation expected to be required more than 48 hours.
Signed informed consent.

Exclusion Criteria6

Patients under mechanical ventilation with pre-existing gastrointestinal issues.
Diagnosis of adult congenital heart disease.
Ongoing pregnancy or lactation period.
Simultaneous participation in another clinical study involving experimental therapy.
Presence of chronic intestinal disease.
Previous gastrointestinal conditions detected during nutritional screening.