RecruitingPhase 4NCT06523465

Statin Combined with Amlodipine Treats Primary Aldosteronism

A Prospective, Multi-center, Randomized Trial to Compare Statin Combined with CCB to MRA Combined with CCB in Primary Aldosteronism Treatment


Sponsor

Third Military Medical University

Enrollment

180 participants

Start Date

Sep 10, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

The drug treatment for primary aldosteronism (PA) is limited and difficult to improve long-term cardiovascular outcomes. This study plans to enroll patients with primary aldosteronism and randomly divide into 3 groups: scheme 1: Statin combined with amlodipine besylate, scheme 2: Statin combined with Spironolactone and Amlodipine besylate. scheme 3: Amlodipine besylate combined with Spironolactone , to observe the changes in plasma aldosterone level, 24-hour urinary aldosterone, blood pressure, and long-term cardiovascular risk.


Eligibility

Min Age: 18 YearsMax Age: 70 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether a combination of two blood pressure medications — a statin (typically used for cholesterol) and amlodipine (a calcium channel blocker) — can effectively treat primary aldosteronism, a condition where the adrenal glands produce too much of a hormone called aldosterone, leading to high blood pressure. **You may be eligible if...** - You have been clinically diagnosed with primary aldosteronism **You may NOT be eligible if...** - You are allergic to any of the medications used in this study - You are pregnant - You have severe liver or kidney disease - You have a mental illness Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGSimvastatin combined with Amlodipine besylate

6-month treatment of Simvastatin combined with Amlodipine besylate

DRUGSimvastatin combined with Spironolactone and Amlodipine besylate.

6-month treatment of Simvastatin combined with Spironolactone and Amlodipine besylate.

DRUGAmlodipine besylate combined Spironolactone

6-month treatment of Amlodipine besylate combined with Spironolactone


Locations(1)

No. 10 Changjiang River Branch, Yuzhong District,Chongqing, China

Chongqing, Chongqing Municipality, China

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NCT06523465


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