Study on Multimodal Imaging and Molecular Imaging Techniques in Degenerative Dementia

This study uses advanced brain imaging techniques — including MRI and PET scans — alongside blood and spinal fluid biomarkers to improve understanding of Alzheimer's disease and other types of memory loss (dementia or mild cognitive impairment). Researchers aim to use multiple imaging tools simultaneously to better identify these conditions early, track their progression, and find patterns that could help with earlier diagnosis and treatment. **You may be eligible if...** - You are 50 to 85 years old (male or female) - You have been diagnosed with dementia or mild cognitive impairment (MCI) - Your score on standard memory tests (MMSE 15-28, CDR ≤1) falls within the mild-to-moderate range - You and your family understand the study and have signed informed consent **You may NOT be eligible if...** - You have another brain condition that might explain your memory problems (e.g., depression, brain tumor, Parkinson's disease, epilepsy, brain injury) - You have a systemic illness causing cognitive issues (e.g., thyroid disease, vitamin B12 deficiency, HIV, alcohol abuse) - You have severe cognitive impairment that prevents cooperation with testing - You have a contraindication to MRI (e.g., certain metal implants) - You are unwilling to have a blood draw Talk to your doctor to see if this trial is right for you.