RecruitingNCT06538948

Direct Measurement of Ingestive Behaviour in Relation to Sex Differences and Gastrointestinal Hormone Levels in Patients After Metabolic and Bariatric Surgery


Sponsor

University of Zurich

Enrollment

420 participants

Start Date

Feb 13, 2024

Study Type

OBSERVATIONAL

Conditions

Summary

Bariatric surgery (BS), especially procedures like Sleeve Gastrectomy (SG) and Roux-en-Y gastric bypass (RYGB), is the most effective treatment for obesity. Yet, the exact mechanisms governing its effect are somewhat elusive, with current research mainly focusing on post-operative food intake outcomes based on self-reported data, which might not fully capture the nuanced changes in eating behaviours. To address these gaps, our study plans to employ the newly developed "drinkometer", a device capable of analysing the intricate changes in drinking behaviour following BS. This tool promises to bring a more detailed perspective to the changes in ingestive behaviours, bypassing the inaccuracies of self-reporting methods. By expanding our research to encompass diverse patient demographics and examining potential links to physiological shifts like gut hormone level alterations, the study aims to provide a more rounded understanding of the long-term impacts of BS on eating behaviours.


Eligibility

Min Age: 18 Years

Inclusion Criteria4

  • Age ≥ 18 year
  • BMI ≥ 35 kg/m2 for patients with planned RYGB or SG operation
  • BMI ≥ 30 kg/m2 for external controls affected by obesity but no planned RYGB or SG within the next 12 months, and
  • BMI ≥ 18.5 kg/m2 and ≤ 24.9 kg/m2 for controls without obesity.

Exclusion Criteria4

  • history of previous bariatric operations and/ or revisional surgery (e.g., alteration of limb lengths after primary RYGB),
  • smoking,
  • established diagnosis of type 1 or 2 diabetes mellitus, and
  • polycystic ovary syndrome (PCOS).

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Interventions

PROCEDUREBariatric Surgery

The intervention is not assigned to the participant after recruitment in the study, rather the intervention is an inclusion criteria for participation in the study.


Locations(2)

Hospital Männedorf

Männedorf, Canton of Zurich, Switzerland

University Hospital Zurich, Department of Surgery and Transplantation

Zurich, Canton of Zurich, Switzerland

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NCT06538948


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