fMRI Accelerated TMS Depression

This study uses brain MRI imaging to identify individual patterns of brain connectivity in people with major depression, and then uses those patterns to guide and optimize a non-invasive brain stimulation treatment called accelerated TMS (transcranial magnetic stimulation). **You may be eligible if...** - You are aged 18–65 with a diagnosed major depressive disorder (MDD) - You can provide your own consent and communicate in English **You may NOT be eligible if...** - You cannot have an MRI scan (for example, due to metal implants in the head, heart, or neck) - You have a history of brain surgery, epilepsy, head injury, or moderate to severe traumatic brain injury - You have other active psychiatric or neurological conditions, or a personality disorder - You have a history of heart attack or irregular heart rhythm - You have moderate to severe alcohol or substance use disorder - You are pregnant Talk to your doctor to see if this trial is right for you.