fMRI Accelerated TMS Depression
Tracking Brain Imaging Changes in Depression Over Clinical Accelerated Transcranial Magnetic Stimulation (TMS) Therapy at the Individual Level
Medical University of South Carolina
20 participants
Sep 23, 2024
OBSERVATIONAL
Conditions
Summary
This study aims to investigate whether phenotypic-related brain states revealed by a novel INSCAPE ("Individualized Network-based Single-frame Coactivation Pattern Estimation") neuroimaging method in Major Depressive Disorder (MDD) patients can track brain recovery of MDD patients over an accelerated antidepressant transcranial magnetic stimulation (TMS) treatment.
Eligibility
Inclusion Criteria3
- Age 18-65
- Have the capacity and ability to provide one's own consent in English and sign the informed consent document.
- DSM-IV diagnosis of MDD
Exclusion Criteria12
- Unable to speak English.
- Contraindicated for MRI.
- Any current or recent untreated medical, neurological, or psychiatric conditions
- Metal implant devices in the head, heart, or neck.
- History of brain surgery.
- History of cortisol medication use or electroconvulsive therapy.
- Comorbidity with other psychiatric/neurological illnesses or personality disorders
- History of myocardial infarction or arrhythmia, bradycardia.
- Personal history of head injury, concussion, or self-report of moderate to severe traumatic brain injury.
- Individuals suffering from frequent/severe headaches.
- Moderate to severe alcohol or substance use disorder.
- Pregnancy
Interventions
MRI will be used to observe brain states over time.
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT06562153