A Clinical Trial of LY3962681 in Healthy Volunteers and in Patients With Parkinson's Disease

This study is testing a new experimental drug (LY3962681) to evaluate its safety and how it behaves in the body — first in healthy volunteers, and then in patients with Parkinson's disease. The goal is to establish a safe dose and understand how the drug interacts with disease-related biomarkers. **You may be eligible if...** - For healthy volunteers: you are generally healthy with no significant medical conditions - For Parkinson's patients: you have a confirmed diagnosis of Parkinson's disease with stage 1–2.5 severity (mild-to-moderate, still able to function independently) - Your cognition is intact (Montreal Cognitive Assessment score ≥24) - Your other medications have been stable for at least 8 weeks - Your body weight is between 40–110 kg (about 88–242 pounds) **You may NOT be eligible if...** - You have significant organ problems (heart, liver, kidney, or lung) - You have a history of certain cancers or active infections - You are pregnant or breastfeeding - Your Parkinson's medications are expected to change significantly in the next 6 months - You have had major surgery in the past 3 months Talk to your doctor to see if this trial is right for you.