Phase 2 Study of Ivonescimab in Patients With Cutaneous Squamous Cell Carcinoma

This study tests a new drug called ivonescimab in two groups: people with advanced skin cancer (cutaneous squamous cell carcinoma) that cannot be removed by surgery, and people with prostate cancer that has stopped responding to hormone therapy. The drug targets two pathways that help tumors grow and hide from the immune system. **You may be eligible if:** - You are 18 or older - You have advanced skin cancer that cannot be surgically removed, OR you have prostate cancer that has progressed despite treatment to lower testosterone - You are well enough to be up and about (ECOG score 0 or 1) - Your blood counts, kidney, and liver function are within acceptable ranges - You are willing to use contraception during the study **You may NOT be eligible if:** - You had to permanently stop a previous PD-1 immunotherapy drug due to side effects - You have an active autoimmune disease (some exceptions apply) - You are pregnant or breastfeeding - You have HIV, active hepatitis B or C - You have had an organ transplant - You have active infections requiring IV antibiotics Talk to your doctor to see if this trial is right for you.