Ex Vivo Cutaneous SCC

This study is collecting surgically removed skin tissue from people with cutaneous squamous cell carcinoma (a common type of skin cancer that starts in the outer layer of skin) to study the tumor in a laboratory setting. By analyzing tumor tissue directly after removal, researchers hope to learn more about how this cancer behaves, how it resists treatment, and what new therapies might target it more effectively. **You may be eligible if...** - You are an adult who has been diagnosed with primary cutaneous squamous cell carcinoma (skin cancer arising in your own skin, not spread from elsewhere) - You are having your tumor surgically removed as part of your standard care **You may NOT be eligible if...** - Your tumor is located on sensitive areas such as the eyelids, vulva, penis, or perianal region - The expected size of surgical removal is larger than approximately 2.5 inches (60mm) in diameter - Your doctor determines participation is not appropriate Talk to your doctor to see if this trial is right for you.