RecruitingNCT06571084
New Screening and Diagnostic Cut-off Points of PA Patients
Establishment and Clinical Application Evaluation of Screening and Diagnostic Cut-off Points With Aldosterone and Renin for Primary Aldosteronism Patients
Sponsor
China National Center for Cardiovascular Diseases
Enrollment
770 participants
Start Date
Jan 4, 2024
Study Type
OBSERVATIONAL
Conditions
Summary
This study aims to establish the screening and diagnostic cut-off points for primary aldosteronism patients by a novel small molecule "sandwich method" aldosterone and renin chemiluminescent immunoassay.
Eligibility
Min Age: 18 YearsMax Age: 75 Years
Inclusion Criteria8
- -75y;
- persistent hypertension (BP >150/100 mm Hg), or drug-resistant hypertension;
- newly diagnosed hypertension;
- hypertension and spontaneous or diuretic-induced hypokalemia;
- hypertension with adrenal incidentaloma;
- hypertension and a family history of early-onset hypertension or cerebrovascular accident at a young age (<40 years);
- status as a hypertensive first-degree relative of patients with PA;
- patients with hypertension and obstructive sleep apnea.
Exclusion Criteria8
- age <18; BMI ≤ 18.0kg/m2 or ≥ 35.0 kg/m2;
- a diagnosis of secondary hypertension other than PA;
- chronic cardiac dysfunction (NYHA III-IV);
- medium and several kidney dysfunction (Ccr<30ml/min);
- liver cirrhosis;
- terminal malignant tumor;
- recent use of steroids or oral contraceptives;
- pregnancy or lactation.
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Locations(1)
View Full Details on ClinicalTrials.gov
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NCT06571084
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