Thoracic Fluid Content During Stabilization and Therapeutic De-escalation in Septic Shock
Assessment of Intra-thoracic Water by Bio Reactance During Stabilization and Therapeutic De-escalation in Septic Shock: A Prospective, Multicenter, Observational Study
University Hospital, Brest
50 participants
Jun 1, 2023
OBSERVATIONAL
Conditions
Summary
In ICU, fluid challenge represents one of the cornerstones of hemodynamic care. However, fluid overload due to an excessive and/or inappropriate fluid administration could be associated with morbidity or mortality. Unfortunately, there is currently no continuous non-invasive devices to monitor fluid content at bedside. Bio reactance is a non-invasive, rapid and continuous technology developed in order to measure body fluid compartment. Monitoring devices functioning with such technology are promising to evaluate fluid overload in ICU.
Eligibility
Inclusion Criteria6
- Adult (Age >18 years old)
- Septic shock according to Sepsis-3 definition:
- A suspected or confirmed infection
- Persisting hypotension, despite adequate fluid resuscitation, requiring vasopressor to maintain a Mean Arterial Pressure (MAP) ≥ 65 mmHg
- Lactate level > 2 mmol/l
- Predictive ICU length of stay > 3 days
Exclusion Criteria5
- Admission in ICU for more than 3 days
- Refusal to participate
- Moribund patients
- Decision of therapeutic withdrawal
- Curators
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Locations(2)
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NCT06572995