RecruitingPhase 1Phase 2NCT06575075

Pilot Study of RR-HNK in OCD

A Double-blind, Placebo-controlled Study to Determine the Safety and Feasibility of Two Doses of Intravenous (2R, 6R)-Hydroxynorketamine (RR-HNK) in Adults With Obsessive-Compulsive Disorder


Sponsor

Carolyn Rodriguez

Enrollment

45 participants

Start Date

Jan 23, 2026

Study Type

INTERVENTIONAL

Conditions

Summary

The purpose of this study is to understand how RR-HNK works in the brain to bring about a reduction in OCD symptoms.


Eligibility

Min Age: 18 YearsMax Age: 65 Years

Plain Language Summary

Simplified for easier understanding

This pilot study tests a compound called RR-HNK (a metabolite related to ketamine) delivered by infusion for people with obsessive-compulsive disorder (OCD) that has not responded to standard treatments. It aims to see whether this approach is safe and shows any early signs of benefit. **You may be eligible if...** - You are between 18 and 65 years old - You have been diagnosed with OCD - You have tried and failed at least one standard OCD treatment (such as an SRI medication or cognitive behavioral therapy), or have declined these for personal reasons - You are willing to fast before infusion sessions and follow study procedures **You may NOT be eligible if...** - You have an allergy or sensitivity to ketamine - You have a medical or psychiatric condition that makes participation unsafe - You are pregnant, breastfeeding, or able to become pregnant without using effective contraception Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGRR-HNK/Hydroxynorketamine

(2R,6R)-Hydroxynorketamine is a metabolite of the drug ketamine and a glutamate AMPA receptor antagonist.

DRUGPlacebo

Sterile Saline


Locations(1)

Stanford University School of Medicine

Palo Alto, California, United States

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NCT06575075


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