ClinicalTrialsFinder
RecruitingPhase 1Phase 2NCT06575075

Pilot Study of RR-HNK in OCD

A Double-blind, Placebo-controlled Study to Determine the Safety and Feasibility of Two Doses of Intravenous (2R, 6R)-Hydroxynorketamine (RR-HNK) in Adults With Obsessive-Compulsive Disorder

Sponsor

Carolyn Rodriguez

Enrollment

45 participants

Start Date

Jan 23, 2026

Study Type

INTERVENTIONAL

Conditions

Obsessive-Compulsive Disorder

Summary

The purpose of this study is to understand how RR-HNK works in the brain to bring about a reduction in OCD symptoms.

Eligibility

Min Age: 18 YearsMax Age: 65 Years

Inclusion Criteria5

  • Ages 18-65
  • Meet the criteria for OCD diagnosis
  • Failed at least 1 prior trial of standard first-line OCD treatment (e.g. SRI/CBT) or or had refused these treatments for individual reasons
  • Agree to the following lifestyle modifications: comply with requirements for fasting prior to --the infusion session, not enroll in any other interventional clinical trials during the duration of the study, and commit to medication study procedures.
  • Able to provide informed consent

Exclusion Criteria4

  • Allergy or hypersensitivity to ketamine
  • Any current or past medical/psychiatric condition that makes participation unsafe in the opinion of the investigator or study physician
  • Pregnant or nursing, or able to become pregnant and are not practicing an effective means of birth control
  • Lifetime history of deep brain stimulation

Interventions

DRUGRR-HNK/Hydroxynorketamine

(2R,6R)-Hydroxynorketamine is a metabolite of the drug ketamine and a glutamate AMPA receptor antagonist.

DRUGPlacebo

Sterile Saline

Locations(1)

Stanford University School of Medicine

Palo Alto, California, United States

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT06575075

Related Trials

A Multicenter Pediatric Deep Brain Stimulation Registry

NCT065856181 location

MDMA-Assisted CBT for OCD (MDMA-CBT4OCD Study)

NCT057838171 location

Neurostimulation Versus Therapy for Problems With Emotions

NCT057120571 location

University of Iowa Interventional Psychiatry Service Patient Registry

NCT044809181 location

Developing Brain, Impulsivity and Compulsivity

NCT046310421 location