RecruitingPhase 4NCT06578234

Hyperemic mYocardial Perfusion by adEnosine at diffeRent Doses

Sponsor

Region Skane

Enrollment

180 participants

Start Date

Oct 23, 2024

Study Type

INTERVENTIONAL

Conditions

Coronary Artery Disease Chronic Coronary Syndrome Ischemic Heart Disease

Summary

Adenosine is a commonly used pharmaceutical stressor at cardiac magnetic resonance examinations to assess suspected chronic coronary syndrome (CCS). However, several studies have reported that the current use of adenosine does not induce adequate hyperemic response in a substantial number of patients, leading to false diagnostics. The aim of this trial is to investigate the hyperemic effect of the standard dose of adenosine (140 microgram/kg/min) to the high dose of adenosine (210 microgram/kg/min) to improve the diagnostic methods using adenosine as a stressor and ultimately improve treatment decisions and patient prognosis in CCS.

Eligibility

Min Age: 40 Years

Inclusion Criteria7

Patients:
The subject has given their written consent to participate in the trial.
Are referred to Department of Clinical Physiology, Skåne University Hospital, for suspected or known CCS or heart failure
No caffein intake <24h prior to the examination
Healthy volunteers:
The subject has given their written consent to participate in the trial.
No caffein intake <24h prior to the examination

Exclusion Criteria26

Patients:
Acute referral (in-house patients)
Clinically unstable
Acute chest pain
Severe or decompensated heart failure
Non sinus rhythm (e.g. atrial fibrillation)
Asthma or severe chronic obstructive pulmonary disease
Known chronic renal failure (eGFR <45mL/min/1.73m2)
AV-block II or III
Left Bundle Branch Block
Systolic blood pressure <90 mmHg or >230 mmHg at rest
Increased intracranial pressure
Known allergy or adverse reaction to adenosine or mannitol
Known allergy or adverse reaction to gadolinium contrast agents
Treatment with medication containing dipyradimol or teofyllamin/teofyllin
Claustrophobia
Devices contraindicated to CMR imaging (pacemaker, implants, intracranial clips etc)
Pregnancy or breast feeding (screened by question only)
Inability to give informed consent due to mental state, language difficulties etc
Healthy volunteers:
Blood pressure > 140/90 measured according to clinical routine
Known systemic disease
Known cardiac disease
Cardiovascular medication
Medication that might influence cardiovascular health
Smoking