Investigation of β-hydroxybutyrate Supplementation as Chemoprevention in Familial Adenomatous Polyposis

This study is testing whether beta-hydroxybutyrate (BHB) supplements — a compound naturally produced during low-carb or fasting states — can help prevent polyps from growing in people with familial adenomatous polyposis (FAP), a genetic condition that causes many colon polyps and increases cancer risk. **You may be eligible if...** - You have been diagnosed with FAP (a genetic condition causing many colon polyps), confirmed by genetic testing or clinical diagnosis - You have already had a large portion of your colon surgically removed (subtotal colectomy or total colectomy with a pouch) - You still have remaining bowel tissue where polyps can develop (rectum, pouch, or small intestine) **You may NOT be eligible if...** - You have not had the required type of bowel surgery - You have active cancer (not just polyps) - You have serious liver, kidney, or metabolic conditions - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.