Intraoral Hypothermia Device for Preserving Taste During Radiation

This study is testing a device worn in the mouth during radiation therapy for throat/larynx cancer to cool the taste glands and try to preserve the sense of taste, which is often damaged by radiation treatment. **You may be eligible if...** - You are 18 years or older - You have been diagnosed with locally advanced squamous cell carcinoma of the larynx (throat cancer) - You are receiving combined radiation and chemotherapy (definitive chemoradiation) as treatment - You are in good physical condition (ECOG 0–1) - You are able to complete questionnaires about taste and quality of life **You may NOT be eligible if...** - You have had prior radiation therapy to the head or neck - You have certain dental or mouth conditions that prevent wearing the device - You are pregnant Talk to your doctor to see if this trial is right for you.