RecruitingPhase 2NCT06580002

Repurposing Riluzole for Cancer-Related Cognitive Impairment: A Pilot Trial

Repurposing Riluzole for Augmenting Brain-Derived Neuropathic Factor (BDNF) Levels and Cognitive Function in Patients Experiencing Cancer-Related Cognitive Impairment: An Interventional Pilot Clinical Trial


Sponsor

University of California, Irvine

Enrollment

51 participants

Start Date

Dec 2, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

This is a phase 2a, randomized, double-blinded, placebo-controlled pilot clinical trial determining the impact of riluzole therapy on circulating brain derived neuropathic factor (BDNF) levels of cancer survivors with cancer related cognitive impairment.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This pilot trial is testing riluzole — a drug already approved for ALS — to see if it can help with the brain fog and memory problems that cancer survivors often experience after treatment. This side effect is sometimes called "chemo brain." Participants take riluzole and complete cognitive assessments to track any improvements. **You may be eligible if...** - You have been treated for breast cancer (any type of treatment) or received certain chemotherapy drugs (anthracyclines or platinum-based) for any cancer in the past 3 years - You feel your thinking or memory has gotten worse since your cancer diagnosis or treatment - You are 18 or older and can read/write in English, Chinese, Korean, Vietnamese, or Spanish **You may NOT be eligible if...** - You have cancer that has spread to the brain - You are pregnant, breastfeeding, or planning to become pregnant during the study - You are unwilling to complete cognitive tests Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGRiluzole

Given PO

DRUGPlacebo

Given PO


Locations(1)

Chao Family Comprehensive Cancer Center, University of California Irvine

Orange, California, United States

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NCT06580002


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