RecruitingNot ApplicableNCT06580249

Efficacy and Mechanism of rTMS on the Symptoms of Pleasure Deficit in Adolescent Depression

Efficacy and Mechanism of Repetitive Transcranial Magnetic Stimulation on the Symptoms of Pleasure Deficit in Adolescent Depression

Sponsor

Xijing Hospital

Enrollment

44 participants

Start Date

Sep 5, 2024

Study Type

INTERVENTIONAL

Conditions

Depression

Summary

(1) Primary objective: to collect data on the score of pleasure deficit scale before and after repetitive transcranial magnetic stimulation treatment in adolescent depressed patients, and to verify its efficacy and safety in adolescent depressed patients in combination with the changes of clinical symptoms; (2) Secondary objective: to explore the relevant hemodynamic mechanisms in adolescent depressed patients before and after repetitive transcranial magnetic stimulation treatment.

Eligibility

Min Age: 10 YearsMax Age: 19 Years

Inclusion Criteria8

Age 10-19 years old (both 10 and 19), gender is not limited;
Meet the criteria for diagnosing MDD in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5);
First episode or relapse, monophasic or bipolar depressive disorder;
No history of any form of antidepressant treatment (including medication, physical and psychotherapy) within 2 weeks prior to enrollment;
Habitual right-handedness;
Deficit of pleasure scale (DARS) \<22 points;
Score \>17 on the 17-item version of the Hamilton Depression Scale (HAMD-17);
After fully understanding the safety of rTMS, they were willing to actively cooperate with the treatment and signed an informed consent form.

Exclusion Criteria5

Complicated with psychotic symptoms;
Comorbidity with major psychiatric disorders such as schizophrenia, delusional disorder, delirium, neurocognitive disorder, intellectual disability, and other mental disorders caused by other diseases;
History of primary neurologic disease or brain injury;
History of electroconvulsive therapy;
Contraindications to rTMS treatment, including cardiac pacemakers, neurostimulators, artificial metal heart valves, intracranial aneurysm clips, cochlear implants, and other types of metal implants (with the exception of oral supports);(6)History of epilepsy.

Interventions

DEVICERepetitive transcranial magnetic stimulation

The true stimulus group acted directly, whereas the pseudo stimulus group reversed the head to produce no effect. Both groups were treated with sertraline medication。