Metastasis-directed Therapy in Oligoprogressive Castration-refractory Prostate Cancer

This study is testing whether targeted radiation therapy aimed at the small number of lesions that are progressing (growing) in prostate cancer can help delay the need for additional systemic treatment in men with castration-resistant prostate cancer (cancer that keeps growing despite hormone therapy). **You may be eligible if...** - You are 18 or older with confirmed prostate cancer (acinar adenocarcinoma) - Your cancer continues to grow on hormone therapy (testosterone level below 50 ng/dL) - You have a small number of progressing lesions (up to 3) on imaging - Your primary prostate tumor has already been treated with surgery or radiation - Your overall health is acceptable (WHO performance status 0–2) **You may NOT be eligible if...** - You have more than 3 progressive lesions - You have uncontrolled pain from bone metastases - You have already received a full course of certain systemic therapies - You have active other malignancies - You have had prior pelvic radiation that prevents re-treatment of the area Talk to your doctor to see if this trial is right for you.