A Biospecimen Collection Study to Identify the Targets of Disease-Reactive T Cells in Patients With Autoimmune Disease

This study is trying to understand what part of the immune system is attacking the body in people with autoimmune diseases. Researchers will collect small tissue or blood samples to study specific immune cells (called T cells) and what they are targeting. **You may be eligible if...** - You are 18 or older - You have been diagnosed with (or are suspected to have) an autoimmune condition such as Crohn's disease, ulcerative colitis, celiac disease, ankylosing spondylitis, multiple sclerosis, scleroderma, or another autoimmune disease - You are currently on a disease-modifying treatment that does not directly destroy T cells (such as Humira, Remicade, Tysabri, Ocrevus, or similar) - You are a good candidate for a tissue biopsy or sample collection procedure **You may NOT be eligible if...** - You are currently taking T cell-toxic medications like methotrexate, azathioprine, steroids (prednisone), JAK inhibitors (e.g., Xeljanz, Rinvoq), or certain other immunosuppressants that cannot be held for at least 4 weeks - You are pregnant or nursing - You have dementia or a condition that prevents you from giving informed consent - You have a serious allergy to local anesthetics (e.g., lidocaine) Talk to your doctor to see if this trial is right for you.