RecruitingNot ApplicableNCT06595654

Treatment of Negative Symptoms of Schizophrenia by rTMS

Treatment of Negative Symptoms of Schizophrenia by Repetitive Transcranial Magnetic Stimulation: A Naturalistic Study

Sponsor

Centre hospitalier de Ville-Evrard, France

Enrollment

124 participants

Start Date

Jun 9, 2023

Study Type

INTERVENTIONAL

Conditions

Schizophrenia Negative Symptoms in Schizophrenia

Summary

The purpose of this study is to assess the effectiveness of rTMS on the negative symptoms of schizophrenia in real conditions. It will also provide a regulatory framework to rTMS treatments under these conditions. 4 types of rTMS protocols are proposed, allowing to adapt to patients and their tolerances.Treatment lasts between 2 and 4 weeks, with a follow-up period of 3 months after treatment to observe relapses.To assess the evolution of negative symptoms between baseline and the end of treatment, investigators use SANS (Scale for the Assessment of Negative Symptoms).

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether repetitive magnetic brain stimulation (rTMS) can help reduce the "negative symptoms" of schizophrenia — things like low motivation, emotional flatness, and social withdrawal — that often don't improve with medication alone. **You may be eligible if...** - You are 18 or older - You have been diagnosed with schizophrenia - Your medication has been stable for at least 4 weeks - You mainly experience negative symptoms (low drive, flat mood) rather than hallucinations or delusions - You speak French - You are affiliated with a social security scheme **You may NOT be eligible if...** - You have a metal implant in your skull, an unstabilized seizure disorder, a cochlear implant, or a pacemaker - You have an unstable medical condition - You are pregnant, breastfeeding, or of childbearing potential without effective contraception Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERrepetitive Transcranial Magnetic Stimulation

* Patient is in a chair. * Hearing protection will be implemented. * The corresponding targeting method will be implemented. * The stimulation coil will be set up according to the indications of the targeting method. * A caregiver is present throughout the session. * After the session, the patient is re-assessed clinically for possible adverse effects. * If an adverse reaction is objectified, a doctor on site, is quickly mobilized.