RecruitingNot ApplicableNCT06596187

Differential Assessment of Hypertonia

Differential Assessment of Hypertonia Related to CNS Impairment


Sponsor

Chang Gung University

Enrollment

45 participants

Start Date

Oct 9, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

Spasticity and rigidity are common symptoms of central nervous system injuries, such as spinal cord injury and Parkinson's disease, and result in distinct patterns of increased resistance during passive joint movements. Spasticity is characterized by a velocity-dependent increase in stretch reflexes, accompanied by exaggerated tendon responses, while rigidity is marked by consistent resistance throughout the range of motion, traditionally considered independent of stretch velocity. However, recent studies suggest that rigidity may also be influenced by stretch velocity. This study aims to investigate muscle tone by examining spasticity, rigidity, and normal muscle function through neural and biomechanical changes. Standard clinical tools, such as the Modified Ashworth Scale and Unified Parkinson's Disease Rating Scale, along with additional assessments like the Myoton and Post-Activation Depression (PAD), will be employed.


Eligibility

Min Age: 20 Years

Plain Language Summary

Simplified for easier understanding

This study is looking at better ways to assess and measure muscle stiffness (hypertonia) in people with neurological conditions like spinal cord injury (SCI) or Parkinson's disease, comparing them to healthy volunteers. **You may be eligible if...** - You have a chronic spinal cord injury (more than one year ago), OR - You have been diagnosed with Parkinson's disease, OR - You are a healthy volunteer **You may NOT be eligible if...** - You have current muscle or joint injuries in your legs - You have osteoporosis - You have any other peripheral or central nervous system disease - You are currently using antispastic or antidepressant medications (for SCI group) - You have active blood clots or osteoporosis (for SCI group) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

PROCEDUREContinuous passive motion device (CPM) of ankle - fast

Continuous passive motion device (CPM) of ankle at 1HZ(60rpm) for 10 repetitions

PROCEDUREContinuous passive motion device (CPM) of ankle - slow

Continuous passive motion device (CPM) of ankle 0.25HZ (15rpm) for 10 repetitions


Locations(1)

Chang Gung University

Taoyuan, Taiwan

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NCT06596187


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