A Study to Evaluate the Efficacy and Safety of HRG2010 in Parkinson's Disease With Motor Fluctuations

This study is testing whether a new drug called HRG2010 can help reduce the unpredictable "off" periods that Parkinson's disease patients experience — times when their levodopa medication stops working and symptoms suddenly worsen. **You may be eligible if...** - You are between 40 and 80 years old - You have been diagnosed with Parkinson's disease - You are taking levodopa with a stable dose but still experience motor fluctuations ("off" periods) - You score 24 or above on the Mini Mental State Exam - You have predictable "off" periods **You may NOT be eligible if...** - You have atypical or secondary parkinsonism (not classic Parkinson's) - You have narrow angle glaucoma, peptic ulcer disease, or GI bleeding history - You have had prior brain surgery for Parkinson's - Levodopa does not work for you - You are pregnant or breastfeeding - You have previously participated in an HRG2010 study Talk to your doctor to see if this trial is right for you.