Pathological Type，Gene Mutation and Clinical Characteristics of Unilateral Primary Aldosteronism
Pathological Type，Gene Mutation and Clinical Characteristics of Unilateral Primary Aldosteronism，A Prospective Study
Qifu Li
100 participants
Dec 1, 2023
OBSERVATIONAL
Conditions
Summary
1. Aim to investigate the pathological feature of UPA in Asians 2. To clarify the relationship between pathology, clinical phenotype, genetic mutation and surgical outcome of UPA in Asians. 3. To explore a new pathological type of unilateral primary aldosterone
Eligibility
Inclusion Criteria3
- No gender limitation;
- Age 18-80 years old;
- The patient was diagnosed with UPA and underwent total adrenal resection.
Exclusion Criteria3
- Bilateral disease
- Partial of no biochemical response in follow-up
- partial adrenalectomy
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Interventions
Whole slide images were created by scanning the complete histologic slide to produce high-resolution digital files of the histopathology of hematoxylin-eosin and CYP11B2 immunostained sections.Tissue sections of all blocks from each resected adrenal were evaluated by hematoxylin and eosin and CYP11B2 immunostaining and adrenal specimens were categorized as classical or nonclassical histopathologic findings of unilateral PA according to the HISTALDO consensus; Genotyping was performed using CYP11B2 (aldosterone synthase)-guided sequencing
Locations(1)
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NCT06597630