A Ketamine-assisted Group Therapy Intervention for Spanish-speaking Adults With Depression

This study is testing ketamine-assisted group therapy for Spanish-speaking Latino adults with depression who have not responded well to standard treatments. Ketamine is an anesthetic agent that has shown rapid antidepressant effects and is being studied in combination with group psychotherapy. **You may be eligible if...** - You identify as Latinx and speak Spanish - You are between 18 and 64 years old - You have been diagnosed with major depressive disorder - You have significant depression symptoms (MADRS score of 20 or above) - You have both an MGB psychiatrist and a primary care provider **You may NOT be eligible if...** - You have a history of schizophrenia, bipolar I disorder, dissociative identity disorder, or neurocognitive disorder - You have unstable complex PTSD - You have a severe or recent substance use disorder - You have uncontrolled high blood pressure or heart disease - You have a history of heart attack, aneurysm, aortic dissection, liver disease, or epilepsy - Your BMI is below 18.5 or above 35 - You are pregnant, breastfeeding, or planning to become pregnant within 12 weeks of finishing treatment Talk to your doctor to see if this trial is right for you.