RecruitingNCT06605417

Understanding the Transition from Normal Melanocytes to Nevus to Melanoma

Understanding the Transition from Normal Melanocytes to Nevus to Melanoma (NevustoMel)

Sponsor

Fundacion Clinic per a la Recerca Biomédica

Enrollment

100 participants

Start Date

Jan 1, 2024

Study Type

OBSERVATIONAL

Conditions

Melanoma (Skin)Nevi and Melanomas Congenital Melanocytic Nevi

Summary

The primary objective of this study is to identify the molecular identity profiles of all cellular states that characterize the progression from benign nevi to malignant melanoma in CAYA patients with L/GCMN. The secondary objectives are: * To longitudinally characterize the cell-free DNA (cfDNA) from CAYA patients. * To improve the early diagnosis and treatments for intermediate conditions such as L/GCMN through evidence-based interpretation of personal risk from endogenous or exogenous sources. * To test pre-clinical strategies to best model and improve patient response.

Eligibility

Plain Language Summary

Simplified for easier understanding

This study examines how normal skin pigment cells (melanocytes) change over time into moles (nevi) and potentially into melanoma, a type of skin cancer. Researchers are studying large congenital nevi — birthmarks present from birth — to better understand the biological process of this transformation. **You may be eligible if...** - You are 18 years or older - You have a large congenital nevus (birthmark) estimated to be approximately 20 cm in size - Biological material (tissue samples) is available for study - You are willing to sign an informed consent form **You may NOT be eligible if...** - No biological material is available for testing - You have not signed informed consent Talk to your doctor to see if this trial is right for you.

This is a simplified summary. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

GENETICMethylomics

Methylomics analysis of FFPE blocks and frozen tissues

GENETICRNA sequencing

RNA sequencing of FFPE blocks and frozen tissues

GENETICSpatial transcriptomics

Spatial transcriptomics of FFPE blocks and frozen tissues

GENETICLiquid biopsy

cfDNA characterization extracted from blood/saliva

Locations(2)

Hospital Clínic de Barcelona (Dermatology service)

Barcelona, Spain

French National Institute of Health and Medical Research

Marseille, France

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NCT06605417

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