Melanoma (Skin) Clinical Trials

21 recruitingLast updated: June 17, 2026

There are 21 actively recruiting melanoma (skin) clinical trials across 9 countries. Studies span Not Applicable, Phase 1, Phase 2. Top locations include Rotterdam, South Holland, Netherlands, Toronto, Ontario, Canada, Heidelberg, Germany. Updated daily from ClinicalTrials.gov.


Melanoma (Skin) Trials at a Glance

21 actively recruiting trials for melanoma (skin) are listed on ClinicalTrialsFinder across 6 cities in 9 countries. The largest study group is Not Applicable with 7 trials, with the heaviest enrollment activity in Rotterdam, Toronto, and Heidelberg. Lead sponsors running melanoma (skin) studies include Centre Hospitalier Universitaire de Nice, University Health Network, Toronto, and D.J. (Dirk) Grünhagen.

Browse melanoma (skin) trials by phase

Treatments under study

About Melanoma (Skin) Clinical Trials

Looking for clinical trials for Melanoma (Skin)? There are currently 20 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Melanoma (Skin) trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Melanoma (Skin) clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 21 trials

Recruiting
Not Applicable

Rural Adult and Youth Sun Protection Study

Skin CancerMelanoma (Skin)
University of Utah843 enrolled2 locationsNCT06439979
Recruiting
Phase 1Phase 2

MC1R-targeted Alpha-particle Monotherapy and Combination Therapy Trial With Nivolumab in Adults With Advanced Melanoma

Metastatic MelanomaMelanoma Stage IVMelanoma Stage III+1 more
Perspective Therapeutics300 enrolled13 locationsNCT05655312
Recruiting

Identification of Metabolic Phenotypes Associated With Melanoma Metastasis

Melanoma (Skin)
University of Texas Southwestern Medical Center400 enrolled1 locationNCT06400550
Recruiting
Phase 2

Phase II Study of Nivolumab in Combination With Relatlimab in Patients With Active Melanoma Brain Metastases

Melanoma (Skin)
M.D. Anderson Cancer Center30 enrolled1 locationNCT05704647
Recruiting
Phase 1

START: Safety and Anti-Tumor Activity of PeptiCRAd-1 in Treatment of Cancer

Triple-Negative Breast CancerColorectal, CancerSarcoma+5 more
Valo Therapeutics Oy15 enrolled7 locationsNCT05492682
Recruiting
Not Applicable

High-Intensity Exercise and High-Fiber Diet for Immunotherapy Outcomes in Melanoma Patients: The DUO Trial

Advanced MelanomaSkin CancerMelanoma (Skin)
Fred Hutchinson Cancer Center40 enrolled2 locationsNCT06298734
Recruiting
Phase 2

Metronomic Cyclophosphamide With Pembrolizumab in Checkpoint Inhibitor Refractory Melanoma

MelanomaMelanoma Stage IVMelanoma (Skin)+1 more
University of California, Irvine14 enrolled1 locationNCT06771544
Recruiting
Phase 1Phase 2

A Phase 1/2 Clinical Trial to Assess the Safety, Tolerability, Pharmacokinetics and Preliminary Efficacy of HMBD-501 in Patients With HER3-Expressing Solid Tumors

Breast CancerNon-small Cell Lung CancerMelanoma (Skin)
Hummingbird Bioscience180 enrolled7 locationsNCT06956690
Recruiting
Not Applicable

Study of Alterations in Tumor Metabolism Associated With the Development of Immunotherapy Resistance in Melanoma

Melanoma (Skin)
Centre Hospitalier Universitaire de Nice20 enrolled1 locationNCT05307289
Recruiting
Not Applicable

Omitting Therapeutic Lymph Node Dissection in Patients With Melanoma (Stage 3) and Major Pathological Response in the Index Lymph Node

Melanoma (Skin)
D.J. (Dirk) Grünhagen213 enrolled1 locationNCT06754904
Recruiting

French Clinical Datbase of Melanoma Patients (RIC-Mel)

Melanoma (Skin)
Nantes University Hospital16,000 enrolled1 locationNCT03315468
Recruiting
Phase 1

A Study to Test the Benefit of Vitamin B5 in Patients With Melanoma

Melanoma (Skin)
University Health Network, Toronto12 enrolled1 locationNCT06377111
Recruiting
Not Applicable

Evaluation of a Personalised Survivorship Care Plan App for Patients With Melanoma

SurvivorshipMelanoma (Skin)Melanoma, Stage II, Stage I+1 more
Erasmus Medical Center180 enrolled4 locationsNCT06643286
Recruiting

Real-life Pharmacological Monitoring of Encorafenib-Binimetinib in the Treatment of Metastatic Melanoma

Melanoma (Skin)
Assistance Publique - Hôpitaux de Paris66 enrolled1 locationNCT06774989
Recruiting

Observational Study of Patients With Advanced Melanoma (Skin Cancer) to Assess if IOpener®-Melanoma Test Can Predict Response to Immunotherapy.

Melanoma (Skin)Melanoma MetastaticMelanoma Advanced+1 more
Pamgene International B.V.196 enrolled3 locationsNCT06784778
Recruiting

Understanding the Transition from Normal Melanocytes to Nevus to Melanoma

Melanoma (Skin)Nevi and MelanomasCongenital Melanocytic Nevi
Fundacion Clinic per a la Recerca Biomédica100 enrolled2 locationsNCT06605417
Recruiting

Genomic Investigation of Unusual Responders

Breast CancerColorectal, CancerCancer+8 more
University Health Network, Toronto100 enrolled1 locationNCT03740503
Recruiting

Versatile Ampification Single-Molecule Detection in Liquid Biopsy

Melanoma Stage IVMelanoma (Skin)Melanoma Stage III+1 more
Regina Elena Cancer Institute20 enrolled1 locationNCT05940311
Recruiting
Not Applicable

DermaSensor Postmarket Surveillance Study

Melanoma (Skin)
DermaSensor, Inc.396 enrolled2 locationsNCT06666790
Recruiting
Not Applicable

Immunological Functionnal Test Validation to Predict Melanoma Metastatic Patient Response to Checkpoint Inhibitors

Melanoma (Skin)
Centre Hospitalier Universitaire de Nice60 enrolled3 locationsNCT05649683