High-Intensity Exercise and High-Fiber Diet for Immunotherapy Outcomes in Melanoma Patients: The DUO Trial

The DUO Trial tests whether a combination of high-intensity exercise and a high-fiber diet can improve how well immunotherapy works in people with advanced melanoma (skin cancer) who are receiving immune checkpoint inhibitor drugs. **You may be eligible if...** - You are 18 or older with advanced melanoma confirmed by tissue testing - You have been receiving or are newly starting immunotherapy (anti-PD1, anti-CTLA4, or anti-LAG3) for at least one month, with plans to continue for at least 8 more weeks - You are not doing enough exercise (less than 150 minutes per week) and not eating enough fiber (less than 30g per day) - Your oncologist has cleared you for high-intensity exercise and a high-fiber diet - You can read and write in English and travel to the study center **You may NOT be eligible if...** - You are receiving other cancer treatments such as chemotherapy or targeted therapy at the same time - You have bone disease at risk of fracture or uncontrolled heart, lung, or metabolic conditions - You are already exercising intensively or already meeting fiber intake guidelines Talk to your doctor to see if this trial is right for you.