Diazoxide Suppression Test P&F Study

This study is testing a medication called diazoxide in people who have insulin resistance — a condition where the body produces too much insulin but it doesn't work properly, often linked to obesity. The goal is to see if the drug can suppress excess insulin, which may help with blood sugar control and weight management. **You may be eligible if...** - You are between 18 and 65 years old - You have a BMI between 30 and 45 (classified as obese) - You have elevated fasting insulin levels (fasting serum insulin ≥ 13 μU/mL) - You have completed a prior insulin sensitivity test (GIST protocol, Group H) - You can read and speak English or Spanish - You can give written informed consent **You may NOT be eligible if...** - You have lost 5% or more of your body weight in the past 3 months - You have uncontrolled high blood pressure (systolic above a set threshold) - You cannot give informed consent in English or Spanish Talk to your doctor to see if this trial is right for you.