U87 CAR-T in Patients With Advanced Head and Neck Tumors

This early-phase study tests a new CAR-T cell therapy (called U87 CAR-T) in people with advanced head and neck cancers that have not responded to standard treatments. CAR-T therapy involves engineering a patient's own immune cells to recognize and attack cancer cells. **You may be eligible if...** - You are between 18 and 70 years old - You have been diagnosed with advanced head and neck cancer confirmed by biopsy - Your cancer has progressed after or is not suitable for standard treatments - You are in good physical health (ECOG 0–1) **You may NOT be eligible if...** - You have active autoimmune disease or are on immune-suppressing medications - You have active, untreated brain metastases - You have serious heart, liver, or kidney problems - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.