RecruitingNot ApplicableNCT06627894

Attenuating DEPression With Internet CBT to Slow Cognitive Decline in Older ICU Survivors(ADEPT-ICU)

Sponsor

Indiana University

Enrollment

300 participants

Start Date

Mar 13, 2025

Study Type

INTERVENTIONAL

Conditions

Depression Cognitive Decline

Summary

Depression affects one-third of intensive care unit (ICU) survivors and represents a potentially modifiable target to slow cognitive decline and reduce the risk of Alzheimer's disease and related dementias (ADRD). Our multi-PI team proposes a two-arm RCT called ADEPT-ICU (Attenuating DEPression with Internet CBT to Slow Cognitive Decline in Older ICU Survivors), which will test the efficacy of an internet CBT intervention called Good Days Ahead (GDA) to reduce the burden of subjective cognitive decline (SCD) in older ICU survivors with moderate to severe depressive symptoms after ICU hospitalization.

Eligibility

Min Age: 50 Years

Plain Language Summary

Simplified for easier understanding

This study (ADEPT-ICU) tests whether an internet-based cognitive behavioral therapy (CBT) program can reduce depression and slow cognitive decline in older adults who experienced depression after surviving a prolonged ICU (intensive care unit) stay. CBT is a structured form of talk therapy delivered online. **You may be eligible if...** - You are 50 years or older - You were in the ICU for more than 48 hours - You have elevated depressive symptoms (based on a PHQ-9 or PHQ-8 questionnaire) - You have noticed changes in your memory or thinking in the past 1–3 years, or scored in the lower 25th percentile on a memory test - You have access to a telephone and are being discharged to home or an assisted living facility **You may NOT be eligible if...** - You are unable to provide informed consent - You have active suicidal ideation - You do not have adequate cognitive function to participate in the program Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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