RecruitingNot ApplicableNCT06628349

Prandial Metabolic Phenotyping in Sarcopenic Older Adults Comparing Plant Based and Whey Based Protein

Sponsor

Texas A&M University

Enrollment

100 participants

Start Date

Feb 1, 2024

Study Type

INTERVENTIONAL

Conditions

Protein metabolism

Summary

The researchers overall objective is to determine whether plant and animal protein based proteins affect the anabolic responses across aging populations differently due to specific changes in the essential amino acids (EAA) and non-essential amino acids (NEAA) kinetic responses. The researchers central hypothesis is that a high EAA to NEAA ratio in a protein meal is related to higher anabolic response to the meal. The researchers also hypothesize that the type of NEAA in a protein meal also affects the anabolic capacity of the meal. The researchers rationale is that finding the amino acid composition of a meal that will maximally induce protein anabolism will guide novel nutritional approaches to prevent and treat sarcopenia, thereby reducing both overall economic burden and improving individual patient outcomes.

Eligibility

Min Age: 50 YearsMax Age: 95 Years

Inclusion Criteria6

Age 50-95 years old
Diagnosis of Chronic Obstructive Pulmonary Disease (COPD); COPD group only
Stable body-weight (±5%) for the past 3 months
Ability to walk, sit down, and stand up (independently or with walking assistance device)
Willingness to lay supine in bed for up to 6 hours
Willingness and ability to comply with the protocol

Exclusion Criteria17

Established diagnosis and active treatment of chronic disease: Insulin dependent diabetes mellitus, active malignancy, heart disease, kidney disease, liver disease, HIV/AIDS, Asthma (moderate to severe), Hep (A,B, or C)
History of untreated metabolic disease including hepatic or renal disorder
Presence of acute illness or metabolically unstable chronic illness
Hysterectomy
Active dependence of alcohol or drugs
Use of short course of oral corticosteroids within 4 weeks preceding study day
Current use of long-term oral corticosteroids
Use of protein or amino acids containing nutritional supplements within 5 days of the first study day
Presence of fever within the last 3 days
Planned elective surgery requiring 2 or more days of hospitalization during the entire study
(Possible) pregnancy
Failure to give informed consent or Investigator's uncertainty about the willingness or ability of the subject
Already enrolled in another clinical trial
Any condition according to the PI or nurse that was found during the screening visit, that would interfere with the study or safety of the patient
Known allergy to any of the components of the feeding (soy, pea, or whey - dairy)
Established daily diet of vegetarian / vegan composition
<23 MoCa score