RecruitingNot ApplicableNCT06629064

Cognitive Control Training for Extinction in PTSD

Identifying Clinically Relevant Neural Circuit Mechanisms of Cognitive Control Training for PTSD


Sponsor

VA Office of Research and Development

Enrollment

120 participants

Start Date

Oct 1, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

The proposed study will test whether a working memory training (WMT) program improves fear extinction learning and its underlying neural circuitry in Veterans with posttraumatic stress disorder (PTSD). WMT is designed to improves the ability to maintain task-relevant information in mind. The project will further validate the relationship between working memory and fear extinction using novel computational and multivariate analyses that link to specific PTSD symptoms. If WMT can enhance fear extinction learning, then WMT may be a powerful adjunctive treatment that can enhance exposure therapy outcomes or be leveraged as a stand-alone treatment. This project supports the Department of Veteran Affairs mission of developing viable targets of treatment for Veterans with PTSD.


Eligibility

Min Age: 18 YearsMax Age: 65 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether a type of brain training called working memory training can help people with PTSD (post-traumatic stress disorder) better process and overcome their fears. Participants complete remote sessions and MRI brain scans before and after the training. **You may be eligible if...** - You are fluent in English - You have been diagnosed with PTSD (per current diagnostic standards) - You are willing to attend 8 remote brain training sessions over 4 weeks - You are willing to have MRI scans before and after training - Your current medications or therapies have been stable for at least 4 weeks **You may NOT be eligible if...** - You have a history of psychotic disorders or bipolar disorder - You have severe substance or alcohol use disorder - You have a history of neurological conditions affecting thinking (e.g., stroke, seizures) - You have moderate to severe traumatic brain injury - You have metal implants or other conditions preventing MRI - You are currently experiencing acute suicidal thoughts requiring immediate help Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALWorking Memory Training

Computer-administered working memory training program. WMT is a modified working memory capacity task designed to train working memory functioning. WMT is designed to contain high interference across trials and is adaptive to performance. As participants improve working memory, the task becomes more difficult.

OTHERSham Training

The Sham condition requires participants to complete a similar computer task for the same length of time. The Sham Training is a modified working memory capacity task designed to place less demands on working memory.


Locations(1)

VA San Diego Healthcare System, San Diego, CA

San Diego, California, United States

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NCT06629064


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