RecruitingNot ApplicableNCT07225049

Integrated PTSD and Chronic Pain Treatment

Pilot of an Integrated Treatment for Comorbid PTSD and Chronic Pain


Sponsor

Weill Medical College of Cornell University

Enrollment

20 participants

Start Date

Dec 8, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

Posttraumatic stress disorder (PTSD) occurs in approximately 7% of adults in the general population. PTSD greatly impacts quality of life and often co-occurs with other conditions such as chronic pain. Individuals with co-morbid PTSD and chronic pain demonstrate higher PTSD symptoms and pain (as well as greater anxiety, depression, disability, and opioid use) compared to those with only one of those conditions. Gold standard treatments exist for both PTSD (e.g., Prolonged Exposure; PE) and chronic pain (e.g., Cognitive Behavioral Therapy for Chronic Pain; CBT-CP) and are generally offered sequentially (i.e., one at a time for the condition that is most prominent). Treating these conditions separately may overlook their interconnected nature, which may reduce efficacy and increase dropout. Thus, there is a need for an intervention to target both simultaneously, which may be more effective and efficient than treating conditions sequentially. This is a single-arm pilot study to assess the feasibility and acceptability of an integrated treatment for adults with comorbid PTSD and chronic pain. The intervention consists of 12 90-minute virtual psychotherapy sessions scheduled twice per week. The treatment draws from modules in PE and CBT-CP including psychoeducation, exposure to feared/avoided situations and activities, processing of exposures, behavioral activation, breathing and relaxation techniques, sleep hygiene, symptom monitoring, and structured homework assignments. Baseline and post-treatment assessments will be conducted.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a combined therapy for adults who suffer from both PTSD (post-traumatic stress disorder) and chronic pain at the same time — a common and challenging combination. The treatment integrates evidence-based approaches for both conditions into a single program delivered as outpatient therapy. **You may be eligible if...** - You are 18 years or older and speak English - You have been diagnosed with PTSD (from any type of trauma) - You have had chronic pain rated at 4 or higher on a 0–10 scale for the past 3 months - You are medically stable and have been on the same psychiatric medications for at least 60 days - You are not currently in another structured therapy program for PTSD or pain **You may NOT be eligible if...** - You have a diagnosis of schizophrenia, another psychotic disorder, or Bipolar I disorder - You have had moderate to severe substance use in the past 90 days - You have significant cognitive impairment that prevents you from completing assessments or consenting - You pose a current risk of harm to yourself or others - You are currently receiving another evidence-based psychological treatment for PTSD or pain Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALIntegrated Treatment for PTSD and Chronic Pain

The intervention consists of 12 90-minute virtual psychotherapy sessions scheduled twice per week. The treatment integrates modules from Prolonged Exposure and Cognitive Behavioral Therapy for Chronic Pain.


Locations(1)

Weill Cornell Medicine

New York, New York, United States

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NCT07225049


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