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RecruitingNot ApplicableNCT06629636

Investigate the Efficacy of Using NMN to Improve Embryo Development Capacity.

Investigate the Efficacy of Using NMN to Improve Embryo Development Capacity and IVF Success Rate in Patients Who Have Experienced IVF Failures.

Sponsor

Sunkaky Medical Cooperation

Enrollment

60 participants

Start Date

Aug 20, 2024

Study Type

INTERVENTIONAL

Conditions

Female InfertilityRepeated IVF Failure

Summary

The objective of this study is to investigate the efficacy of NMN supplementation in enhancing embryo developmental capacity and improving IVF success rates in patients experiencing IVF failures.

Eligibility

Sex: FEMALEMin Age: 32 YearsMax Age: 42 Years

Inclusion Criteria6

  • Agree to participate in the study
  • -42 years old
  • Having at least one previous embryo implantation failure
  • History of low Embryo quality at day3 or day5 (according to Veeck's and Gardner's Criteria)
  • No major uterine or ovarian abnormalities
  • BMI level 18-25kg/m2

Exclusion Criteria12

  • Ovarian endometriosis with Chocolate cysts (AFS type 3 and 4)
  • Patients who have taken different supplements such as coenzyme Q10, vitamin E, carnitine,niacin, nicotinamide, or other vitamin B3-related etc. within the previous month
  • Any medical contraindication of oocyte retrieval or subsequent procedures
  • Couples where the husband presents with severe sperm abnormalities
  • Couples where the husband presents \<5 million/mL motile sperm
  • Uterine structural anomalies
  • Polycystic ovaries
  • Premature ovarian failure
  • Individuals who need regular medication to treat chronic diseases such as diabetes, hypertension, gout, hyperuricemia, etc.
  • Individuals who need drug treatment for any mental illness such as epilepsy and depression.
  • Individuals who suffer from infectious diseases such as hepatitis B, active tuberculosis, AIDS, etc.
  • Cancer patients or receiving chemo/radiotherapy treatment within the past 3 years.

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Interventions

DIETARY_SUPPLEMENTNMN capsule

Total of 900mg/day for 8 weeks

OTHERPlacebo

NMN-free placebo capsules for 8 weeks

Locations(1)

IVF Namba Clinic, Sankaky Medical Corporation

Osaka, Osaka, Japan

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NCT06629636

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