Fatigue and Molecular Mechanisms in Cancer Patients Receiving CCRT
An Evaluation of Changes in the Relationships Between Fatigue and Molecular Mechanisms in Cancer Patients Receiving Curative-Intent Combined Chemotherapy and Radiation Therapy (CCRT)
University of California, San Francisco
125 participants
Dec 27, 2024
OBSERVATIONAL
Conditions
Summary
Cancer-related fatigue (CRF) is a significant problem for cancer patients. This prospective, basic science, observational study will evaluate for changes in CRF associated with molecular characteristics prior to, during, and at the completion of non-investigational, standard-of-care, combined chemotherapy and radiation therapy (CCRT) and to develop and assess predictive models for CRF severity.
Eligibility
Inclusion Criteria7
- Participants have not received any prior treatment (i.e., cancer systemic therapies or radiation therapy) in the month except surgery or inductive Chemotherapy (CTX).
- Participants receiving \>= 15 fractions.
- Participants is male or female and is \>18 years of age on the day of signing the informed consent.
- Ability to understand a written informed consent document.
- Able and willing to complete all of the study questionnaires and provide blood and stool samples prior to, midway, and following the completion of treatment.
- Willing to have medical records reviewed for clinical information.
- Able to read, write and understand English or Spanish.
Exclusion Criteria1
- Contraindication to phlebotomy for removal of approximately 50 mL of peripheral blood within 6 week period (Institutional Review Board (IRB) limit).
Interventions
Blood samples will be obtained throughout the course of the study
Stool samples will be obtained throughout the course of the study
Surveys will be given throughout the course of the study.
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06633224