Efficacy of MitraCLip Vs. PASCAL for the TrEAtment of MitraL REgurgiTation in an All-comer Population

This study compares two different types of devices — MitraClip and PASCAL — used in a procedure to repair a leaky heart valve (mitral regurgitation) without open-heart surgery. This is called transcatheter edge-to-edge repair (M-TEER). Both devices clip the two leaflets of the valve together to reduce leakage. The study aims to see which works better in a broad, real-world population of patients. **You may be eligible if...** - You are 18 or older - Your heart care team has recommended M-TEER for your leaky mitral valve - You can provide written informed consent **You may NOT be eligible if...** - You have mitral stenosis (a narrowed, stiff valve, rather than a leaky one) - You are in cardiogenic shock or hemodynamically unstable at the time of the procedure - You have active infection of the heart valves (endocarditis) - You are participating in another interventional heart study Talk to your doctor to see if this trial is right for you.