Assessing Improvements in Mood and Sleep Trial

This study (AIMS Trial) tests treatments to improve mood and sleep in older adults (55+) who have depression with suicidal thoughts and significant sleep problems that have not improved on antidepressants. Researchers want to find better combinations of therapy and medication for this difficult-to-treat group. **You may be eligible if...** - You are 55 years old or older - You are currently taking an antidepressant medication at the proper dose for at least 4 weeks - You have significant depression symptoms (PHQ-9 score ≥ 10) - You have suicidal thoughts (Scale for Suicide Ideation score ≥ 3) OR a history of a suicide attempt - You have significant sleep disturbance or impairment **You may NOT be eligible if...** - You have active suicidal plans or are currently hospitalized for psychiatric reasons - You have bipolar disorder, a psychotic disorder, or borderline personality disorder - You are currently in active cognitive-behavioral therapy or receiving ketamine, ECT, or TMS - You have a life-limiting illness with less than 1 year to live - You have a moderate to severe substance use disorder - You work night shifts Talk to your doctor to see if this trial is right for you.