Feasibility of Accelerated, Personalized rTMS as an Adjuvant for Impulse Control Disorders: a Pilot Study

Exclusion Criteria31

• rTMS exposure for treatment or research purposes in the last 6 months.
• History of seizure, epilepsy, syncope, fainting episode, or head trauma resulting in loss of consciousness.
• Presence or history of neurological disorders (migraine, stroke, Alzheimer's Disease and other Dementias, Parkinson's Disease, Multiple Sclerosis, Traumatic Brain Injury (TBI), increased intracranial pressure).
• History of brain surgery, implanted electronic device, metal in the head.
• Cardiac pacemakers, neural stimulators, implantable defibrillator, implanted medication pumps or sensors, intracardiac lines, or acute, unstable cardiac disease, with intracranial implants (e.g., aneurysm clips, shunts, stimulators, cochlear implants, or electrodes)
• History of or currently under medical care for myocardial infarction, angina, congestive heart failure, cardiomyopathy, stroke, or transient ischemic attack.
• Reported history of vision problems that are not treated.
• Has a hairstyle not compatible with the EEG net that is required to be worn on the scalp during the experimental procedure.
• Reports current diagnosis or history of type I diabetes.
• Currently using insulin.
• Have undergone bariatric surgery.
• Currently being enrolled in a weight loss program
• Takes any prescription or over the counter medications or supplements to control weight and/or appetite.
• Self-report a history of or current diagnosis of a mental health condition.
• Reports insomnia (<4 hours sleep per night, in 3 or more nights per week in the last 3 months)
• Reports (<4 hours of sleep) the day of the visit.
• Reports using marijuana on a daily basis.
• Reports having used any other illicit drugs (other than marijuana) or prescription medications for non-medical reasons in the last 12 months.
• Currently receiving treatment for substance use disorder (e.g., alcohol, opioids, cocaine, marijuana, or stimulants).
• Females who report averaging more than 7 alcoholic drinks, or males who report averaging more than 14 alcoholic drinks in a single week in the last 30 days.
• Current use of certain medications (last 3 months):
• Investigational drugs.
• Drugs of anti or pro-convulsive action. Medications with psychotropic effects (e.g., antidepressants, antipsychotics).
• Medications known to increase risk of seizure taken within 1 week of enrollment.
• Smoking cessation medication (e.g., Zyban, Wellbutrin, Wellbutrin SR, Chantix).
• Being pregnant or lactating
• Reported allergies to chocolate or any ingredient in the M\&M candies.
• Noise-induced hearing loss or tinnitus.
• Currently participating in any other research study.
• Any otherwise not specified medical or psychiatric condition, illness, disorder, or concomitant medication that could compromise participant safety or treatment, as determined by the Principal Investigator and/or Study Physician
• Subjects considered by the investigator as unsuitable for the study for reasons not otherwise stated.